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2039-2060
| Secretase Targets for Alzheimer's Disease: Identification and Therapeutic Potential
Michael S. Wolfe
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2061-2064
Design and Synthesis of 2-Methyl-2-{4-[2-(5-methyl-2-aryloxazol- 4-yl)ethoxy]phenoxy}propionic Acids: A New Class of Dual PPAR / Agonists
Dawn A. Brooks,
Garret J. Etgen,
Christopher J. Rito,
Anthony J. Shuker,
Samuel J. Dominianni,
Alan M. Warshawsky,
Robert Ardecky,
James R. Paterniti,
John Tyhonas,
Donald S. Karanewsky,
Raymond F. Kauffman,
Carol L. Broderick,
Brian A. Oldham,
Chahzrad Montrose-Rafizadeh,
Leonard L. Winneroski,
Margaret M. Faul, and
James R. McCarthy
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2065-2068
Potential New Antitumor Agents from an Innovative Combination of Demethylcantharidin, a Modified Traditional Chinese Medicine, with a Platinum Moiety
Yee-Ping Ho,
Kenneth K. W. To,
Steve C. F. Au-Yeung,
Xinning Wang,
Ge Lin, and
Xiuwen Han
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2069-2072
3-(4-Aroyl-1H-pyrrol-2-yl)-N-hydroxy-2-propenamides, a New Class of Synthetic Histone Deacetylase Inhibitors
Silvio Massa,
Antonello Mai,
Gianluca Sbardella,
Monica Esposito,
Rino Ragno,
Peter Loidl, and
Gerald Brosch
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2073-2079
Transformation of a  -Opioid Receptor Antagonist to a -Agonist by Transfer of a Guanidinium Group from the 5'- to 6'-Position of Naltrindole
Shiv Kumar Sharma,
Robert M. Jones,
Thomas G. Metzger,
David M. Ferguson, and
Philip S. Portoghese
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2080-2093
Adenosine Analogues as Selective Inhibitors of Glyceraldehyde-3-phosphate Dehydrogenase of Trypanosomatidae via Structure-Based Drug Design
Jerome C. Bressi,
Christophe L. M. J. Verlinde,
Alex M. Aronov,
My Le Shaw,
Sam S. Shin,
Lisa N. Nguyen,
Stephen Suresh,
Frederick S. Buckner,
Wesley C. Van Voorhis,
Irwin D. Kuntz,
Wim G. J. Hol, and
Michael H. Gelb
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2094-2107
Development of Potent Non-Carbohydrate Imidazole-Based Small Molecule Selectin Inhibitors with Antiinflammatory Activity
Deborah H. Slee,
Suzanne J. Romano,
Jinghua Yu,
Truc N. Nguyen,
Judy K. John,
Neil K. Raheja,
Frank U. Axe,
Todd K. Jones, and
William C. Ripka
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2108-2117
Bicyclic Analogues of D-myo-Inositol 1,4,5-Trisphosphate Related to Adenophostin A: Synthesis and Biological Activity
Andrew M. Riley,
Vanessa Correa,
Mary F. Mahon,
Colin W. Taylor, and
Barry V. L. Potter
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2118-2132
Synthesis, Biological Evaluation, and Pharmacophore Generation of New Pyridazinone Derivatives with Affinity toward 1- and 2-Adrenoceptors
Roberta Barbaro,
Laura Betti,
Maurizio Botta,
Federico Corelli,
Gino Giannaccini,
Laura Maccari,
Fabrizio Manetti,
Giovannella Strappaghetti, and
Stefano Corsano
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2133-2138
Discovery of 4-Amino-5-(3-bromophenyl)-7-(6-morpholino-pyridin- 3-yl)pyrido[2,3-d]pyrimidine, an Orally Active, Non-Nucleoside Adenosine Kinase Inhibitor
Chih-Hung Lee,
Meiqun Jiang,
Marlon Cowart,
Greg Gfesser,
Richard Perner,
Ki Hwan Kim,
Yu Gui Gu,
Michael Williams,
Michael F. Jarvis,
Elizabeth A. Kowaluk,
Andrew O. Stewart, and
Shripad S. Bhagwat
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2139-2151
Synthesis and Activities of Pyoverdin-Quinolone Adducts: A Prospective Approach to a Specific Therapy Against Pseudomonas aeruginosa
Christophe Hennard,
Que Chi Truong,
Jean-François Desnottes,
Jean-Marc Paris,
Nicole J. Moreau, and
Mohamed A. Abdallah
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2152-2163
Synthesis of Novel -Aminobutyric Acid (GABA) Uptake Inhibitors. 5. Preparation and Structure-Activity Studies of Tricyclic Analogues of Known GABA Uptake Inhibitors
Knud Erik Andersen,
Jan L. S rensen,
Jesper Lau,
Behrend F. Lundt,
Hans Petersen,
Per O. Huusfeldt,
Peter D. Suzdak, and
Michael D. B. Swedberg
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2164-2171
Synthesis, Cytotoxicity, and Antitumor Activity of Copper(II) and Iron(II) Complexes of 4N-Azabicyclo[3.2.2]nonane Thiosemicarbazones Derived from Acyl Diazines
Johnny Easmon,
Gerhard Pürstinger,
Gottfried Heinisch,
Thomas Roth,
Heinz H. Fiebig,
Wolfgang Holzer,
Walter Jäger,
Marcel Jenny, and
Johann Hofmann
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2172-2177
Combinatorial Synthesis of Cholesterol Ester Transfer Protein-mRNA Ligands and Screening by Nondenaturating Gel-Electrophoresis
Michael Baumann,
Hilmar Bischoff,
Delf Schmidt, and
Christian Griesinger,$
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2178-2187
Probing the Interaction of Dengue Virus Envelope Protein with Heparin: Assessment of Glycosaminoglycan-Derived Inhibitors
Rory M. Marks,
Hong Lu,
Renuka Sundaresan,
Toshihiko Toida,
Atsushi Suzuki,
Toshio Imanari,
María J. Hernáiz, and
Robert J. Linhardt
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2188-2203
Amphiphilic Anionic Analogues of Galactosylceramide: Synthesis, Anti-HIV-1 Activity, and gp120 Binding
Barbara Faroux-Corlay,
Jacques Greiner,
Raphaël Terreux,
Daniel Cabrol-Bass,
Anne-Marie Aubertin,
Pierre Vierling, and
Jacques Fantini
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2204-2218
Novel, Potent, and Selective Phosphodiesterase 5 Inhibitors: Synthesis and Biological Activities of a Series of 4-Aryl-1-isoquinolinone Derivatives
Tatsuzo Ukita,
Yoshinori Nakamura,
Akira Kubo,
Yasuo Yamamoto,
Yasunori Moritani,
Kunio Saruta,
Takanori Higashijima,
Jun Kotera,
Michino Takagi,
Kohei Kikkawa, and
Kenji Omori
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2219-2228
5-(Tryptophyl)amino-1,3-dioxoperhydropyrido[1,2-c]pyrimidine-Based Potent and Selective CCK1 Receptor Antagonists: Structure-Activity Relationship Studies on the Substituent at N2-Position
José M. Bartolomé-Nebreda,
Rosario Patiño-Molina,
Mercedes Martín-Martínez,
Isabel Gómez-Monterrey,
M. Teresa García-López,
Rosario González-Muñiz,
Edurne Cenarruzabeitia,
Miriam Latorre,
Joaquín Del Río, and
Rosario Herranz
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2229-2237
Synthesis, Nicotinic Acetylcholine Receptor Binding, and Antinociceptive Properties of 2-exo-2-(2'-Substituted 5'-pyridinyl)-7-azabicyclo[2.2.1]heptanes. Epibatidine Analogues
F. Ivy Carroll,
Feng Liang,
Hernán A. Navarro,
Lawrence E. Brieaddy,
Philip Abraham,
M. I. Damaj, and
Billy R. Martin
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2238-2246
Potent Somatostatin Undecapeptide Agonists Selective for Somatostatin Receptor 1 (sst1)
Jean E. Rivier,
Carl Hoeger,
Judit Erchegyi,
Jozsef Gulyas,
Ryan DeBoard,
A. Grey Craig,
Steven C. Koerber,
Sandra Wenger,
Beatrice Waser,
Jean-Claude Schaer, and
Jean Claude Reubi
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2247-2252
Characterization of Melanocortin NDP-MSH Agonist Peptide Fragments at the Mouse Central and Peripheral Melanocortin Receptors
Carrie Haskell-Luevano,
Jerry Ryan Holder,
Eileen K. Monck, and
Rayna M. Bauzo
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2253-2258
Protease Inhibitors: Synthesis of a Series of Bacterial Collagenase Inhibitors of the Sulfonyl Amino Acyl Hydroxamate Type
Brian W. Clare,
Andrea Scozzafava, and
Claudiu T. Supuran
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